This site needs JavaScript to work properly. Proton pump inhibitor infusion was also started together with high doses of folinic acid. Poisoning with formic acid. Anything above 5 should be considered above average. Learn more here. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA; American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning. These workers often mix FA with alcohol prior to consumption. Despite starting on diuretics initially, the patient was worsening from oliguria to anuria. Although formic acid (FA) poisoning is rare, it is usually fatal. Simplified Approach to Detect Dielectric Constant Using a Low-Cost Microfluidic Quarter Mode Substrate-Integrated Waveguide. 2020 Jul 22;12(8):2181. doi: 10.3390/nu12082181. Privacy Policy Other systemic examinations revealed no abnormalities. The follow-ups were made by three departments: Nephrology, Gastroenterology, and Psychiatry for a more holistic approach. Clipboard, Search History, and several other advanced features are temporarily unavailable. Occupational exposure to vapours of methanol and formic acid can be quantitatively monitored by urinary formic acid determinations. In 2009, the worldwide capacity for producing formic acid was 720 thousand tonnes (1.6 billion pounds) per year, roughly equally divided between Europe (350 thousand tonnes or 770 million pounds, mainly in Germany) and Asia (370 thousand tonnes or 820 million pounds, mainly in China) while production was below 1 thousand tonnes or 2.2 million pounds per year in all other continents. His serum electrolyte reports were potassium 6.5 mmol/L and sodium 135.0 mmol/L. 2 Nearly 90% of cases of formic acid poisoning are with intention of suicide and only 10% are accidental consumption.2 It is observed that most of the victims mix formic acid with alcohol while Besides, urinary acidification is affected by formic acid. (May 06, 2020) An Atypical Presentation of Formic Acid Poisoning. Methanol poisoning cannot cause until it metabolized to formaldehyde/formic acid by enzyme ADH (alcohol dehydrogenase). He was advised for regular follow-ups. Many FA poisoning cases commonly involve rubber plantation workers in which these workers ingest FA accidentally or with suicidal intentions. It has become a mode of suicide because of its easy availability. The man’s renal function test revealed serum urea of 28 mg/dL and creatinine of 1.4 mg/dL. A 73-year-old man with an alleged history of poison consumption was brought to the hospital. Internal Medicine, Osmania Medical College, Hyderabad, IND, Internal Medicine, University of Louisville, Louisville, USA, Internal Medicine, Kasturba Medical College, Manipal, IND. © Copyright 2020Vyata et al. Methanol-induced visual toxicity in the rat. Although formic acid (FA) poisoning is rare, it is usually fatal. Formic acid is directly toxic to the retina, and may lead to blindness. Endoscopy of the upper gastrointestinal tract was deferred to 48 hours later to avoid perforation. Additionally, the patient’s old age likely contributed to his severe prognosis. Urine culture was also observed as the patient was catheterized initially when the sputum sample was analyzed to rule out hidden aspiration pneumonia [2]. Gastrointestinal and psychiatric consultation was given. Life Sci. The body burden of formate in methanol poisoning is high enough to cause acidosis, and other clinical symptoms. This link will take you to a third party website that is not affiliated with Cureus, Inc. The importance of follow-ups in preventing long term complications was conveyed to the family members as well [8]. This acid is an inhibitor of the mitochondrial cytochrome oxidase causing histotoxic hypoxia. Severe poisoning may progress to seizures, coma, and possibly persistent encephalopathy. Reviewing with Cureus is easy, fast and hassle-free! High serum LDH and high CPK enzyme values with normal coagulation confirm the lysis of red blood cells due to metabolic acidosis solely. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. The patient continued to be dialysis dependent and required multiple sessions of hemodialysis. NIH Although pungent and corrosive, FA is usually consumed with alcohol, just as this patient had done [2]. The presence of hemoglobin in urine was indicated by the dark cola color of the urine. Hemodialysis was later performed via his right internal jugular vein.

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