The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins. Those who take statins should check with their doctors to see if it's safe to drink grapefruit juice, which can interact with the drugs. Your risk is less with lower doses of most statins. Precautions. In comparison, fluvastatin is considered a middle-of-the-road tablet that typically is best statin for people with moderately high blood cholesterol. Statins are a class of drugs prescribed to lower blood cholesterol. However, side effects may be a concern, especially if you have effects that are painful or bothersome. A CAC score of zero is associated with a very low CVD event rate and those individuals are unlikely to benefit from statin therapy. Statin Dose Comparison The chart below shows statin doses expected to provide similar LDL reduction. * Online CVD Risk Calculator Go to www.heart.org and search “cv risk calculator” for online web application. Statin drugs can be valuable for managing your LDL and preventing heart disease. The amount, or dose, you need for a statin to be effective is a factor, too. Common side effects of statins are headache, nausea, vomiting, constipation, and diarrhea. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins.Occasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation. CONTRAINDICATIONS:-Hypersensitivity to active substance or any component of product-Active liver disease, which may include unexplained persistent elevations in hepatic transaminase … When choosing a statin dose, expected LDL reduction is not the only factor to consider. Asian patients: Consider starting dose of 5 mg. Limit dose to 20 mg. See statins in Asian patients for more. Your risk is less with lower doses of most statins. * A CAC score ≥100 is associated with an elevated risk of a CVD event (> 20%) regardless of traditional risk factors. 8 - 9 years: 5 - 10 mg once daily; 10 - 17 years: 5 - 20 mg once daily; May take … Most would consider statin doses in this range to be borderng on sub-therapeutic, yet even with this low statin dose, there resulted substantial lowering of cardiovascular disease mortality. In patients with homozygous familial hypercholesterolemia, starting dose of 20 mg is recommended ; May take without regard to food; Dosing - Pediatric. pravastatin or rosuvastatin); consider routine CK monitoring. This can lead to severe muscle pain and kidney damage. Serious side effects can occur. Statins also are prescribed for preventing and treating atherosclerosis. Dosage adjustment may be needed based on renal function, race, or drug interactions. Heterozygous familial hypercholesterolemia. -Intermediate and Low Function SLCO1B1 Phenotype: Initiate therapy with a lower dose or consider an alternative statin (e.g. I cite this study as one of the very first to examine the effectiveness of low doses of statins on cardiovascular disease risk independent of cholesterol effect. Fewer side effects

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